Population
Patients with systemic lupus erythematosus, patients with several other diseases, and normal individuals
Design
Cross-sectional
Authors
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Supports anti-native DNA testing to distinguish active SLE; leaves open prospective validation of diagnostic accuracy in broader populations.
Antibodies to native DNA are highly specific for active systemic lupus erythematosus, distinguishing it from other conditions.
Koffler et al. (1969) studied this question.
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