Key result
IgG and IgM anti-double-stranded RNA antibodies were specifically elevated in the sera of patients with systemic lupus erythematosus compared to normal controls and patients with other rheumatic disorders.
Why the study?
Are anti-double-stranded RNA antibodies specifically elevated in patients with systemic lupus erythematosus compared to other rheumatic diseases and normal controls?
Observational (n=88)
No
Are anti-double-stranded RNA antibodies specifically elevated in patients with systemic lupus erythematosus compared to other rheumatic diseases and normal controls?
Anti-double-stranded RNA antibodies measured by solid-phase radioimmunoassay are specifically elevated in systemic lupus erythematosus and correlate with disease activity.
Answers are grounded in this paper and cite their sources.
Anti-dsRNA antibodies may mark SLE activity; cross-sectional data leave open diagnostic utility pending validation.
Sera from patients with systemic lupus erythematosus (SLE) contain antibodies to a number of nucleic acids. Antibodies to double stranded DNA have been found in patients with SLE, and their titer are generally associated with the disease activity. In this study, the sera from patients with SLE and other rheumatic disorders were examined for antibodies to double-stranded RNA in the major immunoglobulin classes by solid-phase radioimmunoassay employing polystyrene tubes coated with poly-L-lysine. The technique provided high specificity for the antibody to double stranded RNA. The anti-RNA antibodies were found not only in the sera of patients with SLE, but also from patients with other related diseases though less frequently.
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Ninomiya et al. (1982) conducted an observational in Systemic lupus erythematosus and other connective tissue diseases (n=88). Systemic lupus erythematosus vs. Other rheumatic disorders and normal controls was evaluated on IgG and IgM anti-double-stranded RNA antibody levels. IgG and IgM anti-double-stranded RNA antibodies were specifically elevated in the sera of patients with systemic lupus erythematosus compared to normal controls and patients with other rheumatic disorders.
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