Why the study?
What is the incidence of antibodies to double-stranded RNA in patients with SLE compared to normal controls and other diseases?
Population
Patients with systemic lupus erythematosus (SLE) and related diseases, and normal controls
Comparison
Measurement of antibodies to double-stranded RNA… vs Normal controls and patients with other diseases
Design
Cross-sectional
Authors
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Anti-dsRNA antibodies in SLE should not yet change diagnostics; cross-sectional data leave open viral etiology for prospective study.
What is the incidence of antibodies to double-stranded RNA in patients with SLE compared to normal controls and other diseases?
Antibodies to double-stranded RNA are highly prevalent in SLE compared to normal controls and other autoimmune diseases, potentially indicating a response to viral infection.
Schur et al. (1971) studied this question.
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