Why the study?
Are antibodies to reovirus double-stranded RNA present in patients with discoid lupus erythematosus compared to normal controls and other autoimmune diseases?
Are antibodies to reovirus double-stranded RNA present in patients with discoid lupus erythematosus compared to normal controls and other autoimmune diseases?
The presence of similar anti-RNA antibodies in DLE and SLE suggests that DLE may be part of the SLE spectrum.
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May link DLE to SLE spectrum; hypothesis-generating for viral triggers and requires prospective validation.
Antibodies to reovirus double‐stranded RNA (3H‐reovirus RNA) were demonstrated in 23 of 54 sera (42%) of patients with discoid lupus erythematosus (DLE) and 35 of 50 sera (70%) of patients with systemic lupus erythematosus (SLE) using a cellulose ester filter radioimmunoassay. The incidence of antibodies to 3H‐reovirus RNA was 10% in psoriasis, 14% in rheumatoid arthritis, 19% in Sjogren's syndrome and 4% in normal controls. Inhibition studies performed on SLE and DLE sera showed that the anti‐RNA antibodies had similar specificities. These results suggest that DLE may be part of the SLE spectrum.
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Sylvester et al. (1973) studied this question.
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