Key result
Individuals with hypertrophic cardiomyopathy demonstrated higher vagal activity (HF power 7.40 vs. 6.03 ms2, p=0.01) and lower stroke volume index compared to matched healthy controls.
Why the study?
Heart rate variability measures cardiac autonomic function, but differences in HRV and haemodynamic function between individuals with HCM and healthy controls, and their interrelationship, needed evaluation.
Case-Control (n=56)
Absolute Event Rate: 7.4% vs 6.03%
p-value: p=0.01
Individuals with hypertrophic cardiomyopathy exhibit increased vagal activity and altered haemodynamics compared to healthy controls, which can be feasibly assessed using short-term frequency domain indices of HRV.
HRV differences in small HCM cohort are hypothesis-generating; leaves open whether autonomic assessment informs risk or therapy.
Objectives Heart rate variability (HRV) is a measure of cardiac autonomic function. This study: (1) evaluated the differences in HRV and haemodynamic function between individuals with hypertrophic cardiomyopathy (HCM) and healthy controls, and (2) determined the relationship between HRV and haemodynamic variables in individuals with HCM. Methods Twenty‐eight individuals with HCM ( n = 7, females; age 54 ± 15 years; body mass index: 29 ± 5 kg/m 2 ) and 28 matched healthy individuals ( n = 7 females; age 54 ± 16 years; body mass index: 29 ± 5 kg/m 2 ) completed 5‐min HRV and haemodynamic measurements under resting (supine) conditions using bioimpedance technology. Frequency domain HRV measures (absolute and normalized low‐frequency power (LF), high‐frequency power (HF) and LF/HF ratio) and RR interval were recorded. Results Individuals with HCM demonstrated higher vagal activity (i.e., absolute unit of HF power (7.40 ± 2.50 vs. 6.03 ± 1.35 ms 2 , p = 0.01) but lower RR interval (914 ± 178 vs. 1014 ± 168 ms, p = 0.03) compared to controls. Stroke volume (SV) index and cardiac index were lower in HCM compared with healthy individuals (SV, 33 ± 9 vs. 43 ± 7 ml/beat/m², p < 0.01; cardiac index,2.33 ± 0.42 vs. 3.57 ± 0.82 L/min/m 2 , p < 0.01), but total peripheral resistance (TPR) was higher in HCM (3468 ± 1027 vs. 2953 ± 1050 dyn·s ·m 2 cm − 5 , p = 0.03). HF power was significantly related to SV ( r = −0.46, p < 0.01) and TPR ( r = 0.28, p < 0.05) in HCM. Conclusions Short‐term frequency domain indices of HRV provide a feasible approach to assess autonomic function in individuals with HCM. Vagal activity, represented by HF power, is increased, and associated with peripheral resistance in individuals with HCM.
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Alyahya et al. (2023) conducted a case-control in Hypertrophic cardiomyopathy (n=56). Hypertrophic cardiomyopathy vs. Healthy controls was evaluated on High-frequency (HF) power (p=0.01). Individuals with hypertrophic cardiomyopathy demonstrated higher vagal activity (HF power 7.40 vs. 6.03 ms2, p=0.01) and lower stroke volume index compared to matched healthy controls.
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