Why the study?
Does type D retrovirus cause polymyositis in primates with acquired immunodeficiency?
Does type D retrovirus cause polymyositis in primates with acquired immunodeficiency?
Type D retrovirus can cause polymyositis with immunodeficiency in nonhuman primates, suggesting a potential role for retroviruses in human polymyositis.
Answers are grounded in this paper and cite their sources.
Provides no basis for altering human polymyositis care; leaves open a potential retroviral role requiring clinical validation.
Fifty percent of primates with acquired immunodeficiency caused by a well-characterized type D retrovirus (SAIDS D) developed clinical, laboratory, and histologic features of polymyositis. By use of specific antisera and immunochemical techniques, we found the virus in the lymphoid cells surrounding muscle fibers and invading the endomysia septa. SAIDS D virus was isolated from the involved muscles and infected myotubes of normal muscle in tissue culture. These results suggest that retroviruses, a group of viruses increasingly associated with human diseases, can cause polymyositis with immunodeficiency in nonhuman primates and could play a role in human polymyositis.
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Dalakas et al. (1986) studied this question.
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