Association of Circulating Ceramides With Cardiac Structure and Function in the Community: The Framingham Heart Study
Key result
A higher plasma ceramide ratio (C16:0/C24:0) was associated with lower left ventricular ejection fraction (0.991-fold change; P=0.0004) and worse global circumferential strain (β=0.34; P=0.004).
Why the study?
A higher circulating plasma ceramide ratio is associated with increased heart failure risk, but the underlying pathobiological mechanisms remain incompletely understood.
Is a higher circulating plasma ceramide ratio (C16:0/C24:0) associated with adverse cardiac remodeling in a community-based sample?
Population
2652 Framingham Offspring Study participants
Comparison
Circulating plasma ceramide ratio (C16:0/C24:0)
Design
Cross-sectional community-based study
Authors
Discussion
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Member takes
Implication
May link ceramide ratio to HF via remodeling; hypothesis-generating, needs longitudinal studies before clinical or mechanistic use.
Study Design
Type
Cross-Sectional (n=2,652)
Structured PICO
Is a higher circulating plasma ceramide ratio (C16:0/C24:0) associated with adverse cardiac remodeling in a community-based sample?
P
Population
2,652 community-dwelling adults (mean age 66 years, 55% women) from the Framingham Offspring Study who underwent echocardiography and ceramide profiling.
E
Exposure
Higher circulating plasma ceramide ratio (C16:0/C24:0)
O
Outcome
Echocardiographic measures of cardiac structure and function (left ventricular mass, left ventricular ejection fraction, left atrial emptying fraction, left atrial end-systolic volume, E/e', and left ventricular global circumferential and longitudinal strain)surrogate
Main Result
Effect estimate: 0.991-fold change per SD increment
p-value: p=0.0004
Higher circulating plasma ceramide ratio (C16:0/C24:0) is associated with adverse cardiac remodeling traits, potentially explaining its link to clinical heart failure.
Cite This Study
Nwabuo et al. (2019) conducted a cross-sectional in Cardiac remodeling (n=2,652). Plasma ceramide ratio (C16:0/C24:0) vs. Lower ceramide ratio was evaluated on Echocardiographic measures of cardiac structure and function (including left ventricular ejection fraction) (0.991-fold change per SD increment, p=0.0004). A higher plasma ceramide ratio (C16:0/C24:0) was associated with lower left ventricular ejection fraction (0.991-fold change; P=0.0004) and worse global circumferential strain (β=0.34; P=0.004).