Key result
Low exercise cardiac power was associated with a significantly increased risk of heart failure compared with high exercise cardiac power (HR 1.87; 95% CI 1.31-2.66; p<0.001).
Why the study?
Little was known about the effect of exercise cardiac power (ECP) on the risk of heart failure.
Does low exercise cardiac power predict the risk of incident heart failure in men?
Cohort (n=2,351)
Does low exercise cardiac power predict the risk of incident heart failure in men?
Low exercise cardiac power is an independent predictor of incident heart failure in men, though it does not provide incremental prognostic value over maximal oxygen uptake.
BACKGROUND: Little is known about exercise cardiac power (ECP), defined as the ratio of directly measured maximal oxygen uptake with peak systolic blood pressure during exercise, on heart failure (HF) risk. We examined the association of ECP and the risk of HF. METHODS: This was a population-based cohort study of 2351 men from eastern Finland. The average time to follow-up was 25 years. Participants participated at baseline in an exercise stress test. A total of 313 cases of HF occurred. RESULTS: Men with low ECP (<9.84 mL/mmHg, the lowest quartile) had a 2.37-fold (95% confidence interval (95%CI): 1.68-3.35, p < 0.0001) hazards ratio of HF as compared with men with high ECP (>13.92 mL/mmHg, the highest quartile), after adjusting for age. Low ECP was associated with a 1.96-fold risk (95%CI: 1.38-2.78, p < 0.001) of HF after additional adjustment for conventional risk factors. After further adjustment for left ventricular hypertrophy, the results hardly changed (hazards ratio = 1.87, 95%CI: 1.31-2.66, p < 0.001). One SD increase in ECP (3.16 mL/mmHg) was associated with a decreased risk of HF by 28% (95%CI: 17%-37%). CONCLUSION: ECP provides a noninvasive and easily available measure from cardiopulmonary exercise tests in predicting HF. However, ECP did not provide additional value over maximal oxygen uptake
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Kurl et al. (2020) conducted a cohort in Heart failure (n=2,351). Low exercise cardiac power vs. High exercise cardiac power was evaluated on Heart failure (HR 1.87, 95% CI 1.31-2.66, p=<0.001). Low exercise cardiac power was associated with a significantly increased risk of heart failure compared with high exercise cardiac power (HR 1.87; 95% CI 1.31-2.66; p<0.001).
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