Effects and mechanism of renal denervation on ventricular arrhythmia after acute myocardial infarction in rats

Fig. 1. A shows the occurrence frequency of ventricular tachycardia (VT), #RDN-1d + AMI group compared with AMI group, the occurrence frequency of VT decreased, P<0.001; *RDN-2w+AMI group compared with AMI group, VT The number of rapid occurrences decreased, P=0.003, and the difference was statistically significant. B shows the normal ECG of rats and the ECG manifestations of ventricular tachycardia and ventricular fibrillation after AMI

Fig. 2. A shows the HE staining of sympathetic nerves around the renal artery of rats (HE × 200). Compared with the Control group, the structure of sympathetic nerve fibers around the renal artery in RDN group changed, the density of sympathetic ganglia was uneven, atrophied, and the number decreased. B shows the TH staining of the sympathetic nerves around the renal artery in rats (TH×200). Compared with the Control group, the sympathetic nerve activity around the renal artery in the RDN group decreased

Fig. 3. Shows the TH staining of the rat hearts in each group (TH × 200). Compared with the AMI group, the expression of TH in the RDN group was significantly reduced

Fig. 4. Shows the myocardial NGF staining of rats in each group. Compared with the control group, the expression of NGF increased after AMI and the distribution was uneven; compared with the AMI group, the expression of NGF decreased after RDN, and the decrease in the RDN-2w+AMI group was more obvious

Fig. 5. Shows blot image and relative expression level of NGF, a–d Represent the control group, the AMI group, the RDN-1d + AMI group, and the RDN-2w + AMI group, respectively.(Original blot image，see additional file 1-4.)

Fig. 6. A is the sample of renal sympathetic nerve discharge in each group, B is the activity of renal sympathetic nerve discharge, #Compared with the control group, the renal sympathetic nerve discharge in the RDN-1d group was significantly reduced (P<0.001);*Compared with the control group, the renal sympathetic nerve discharge in the RDN-2w group was also significantly decreased (P=0.033)

Fig. 7. Central illustration figure