Why the study?
Does brain angiotensinogen deficiency prevent sympathetic and cardiac dysfunction after myocardial infarction in rats?
Population
Transgenic rats expressing an antisense RNA against angiotensinogen and control Sprague-Dawley rats…
Comparison
Transgenic deficiency in brain angiotensinogen vs Wild-type Sprague-Dawley (SD) rats
Design
Preclinical
Follow-up
8 weeks
Authors
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Brain angiotensinogen deficiency attenuates post-MI LV dysfunction in rats; hypothesis-generating for central RAS inhibition in human HF.
Does brain angiotensinogen deficiency prevent sympathetic and cardiac dysfunction after myocardial infarction in rats?
Brain-derived angiotensin II plays a dominant role in the development of LV dysfunction and sympathetic hyperactivity after myocardial infarction in a rat model.
Wang et al. (2004) studied this question.
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