Key result
Among elderly hospitalized patients taking DOACs, 37% had potential drug-drug interactions, most commonly pharmacodynamic interactions with antidepressants, NSAIDs, and antiplatelets (29%).
Why the study?
What is the prevalence and nature of potential drug-drug interactions with direct oral anticoagulants in elderly hospitalized patients?
Observational (n=122)
No
What is the prevalence and nature of potential drug-drug interactions with direct oral anticoagulants in elderly hospitalized patients?
Potential drug-drug interactions with DOACs are common in elderly hospitalized patients, highlighting the need to carefully consider polypharmacy and bleeding risks in this population.
No takes yet. Share an insight, caveat, or question.
Alerts clinicians to frequent DDIs in elderly DOAC users; leaves open whether screening improves outcomes.
Forbes et al. (2017) conducted an observational in Nonvalvular atrial fibrillation (n=122). Direct oral anticoagulants (DOACs) and potential perpetrator drugs was evaluated on Prevalence of potential drug-drug interactions (DDIs) with DOACs. Among elderly hospitalized patients taking DOACs, 37% had potential drug-drug interactions, most commonly pharmacodynamic interactions with antidepressants, NSAIDs, and antiplatelets (29%).
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