Key result
In a review of five clinical trials, liraglutide use in patients with heart failure was associated with an increase in heart rate, higher rates of hospitalization, and an increased risk of adverse cardiovascular events.
Why the study?
Recent evidence suggested that liraglutide, a GLP-1 analogue used for type 2 diabetes mellitus, might have a beneficial role in treating heart failure.
Does liraglutide improve clinical outcomes in patients with heart failure?
Does liraglutide improve clinical outcomes in patients with heart failure?
This review suggests that liraglutide use in patients with heart failure is associated with increased heart rate, higher hospitalization rates, and increased adverse cardiovascular events, indicating potential harm or lack of benefit in this specific population.
Suggests liraglutide benefit in heart failure; hypothesis-generating pending randomized trials.
Heart failure is a clinical condition in which the heart is unable to maintain adequate cardiac output. Liraglutide is a glucagon-like peptide 1 (GLP-1) analogue that is used for the treatment of type 2 diabetes mellitus, but recent evidence suggests that it might have a beneficial role in treating heart failure. We conducted a review of existing literature and found five relevant studies. Data from these studies were extracted and then extrapolated into results following analysis. Four of the five studies found an increase in heart rate in heart failure patients. All five studies reported an increased rate of hospitalization. The five studies also showed an increased risk of adverse effects such as arrhythmia, ventricular tachycardia, atrial fibrillation, and worsening of heart failure. Given the scarcity of evidence in the available literature on liraglutide in heart failure, more research on this population is required.
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Allam et al. (2023) conducted a review in Heart Failure (n=10,422). Liraglutide vs. Placebo was evaluated. In a review of five clinical trials, liraglutide use in patients with heart failure was associated with an increase in heart rate, higher rates of hospitalization, and an increased risk of adverse cardiovascular events.
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