Key result
Low-dose single-volume quantitative CT myocardial flow measurement accurately correlated with reference microsphere flow in a swine model (Pearson's r = 0.96) and ultrasound in a phantom (r = 0.98).
Why the study?
To validate a low-dose, single-volume quantitative CT myocardial flow technique in a cardiovascular flow phantom and a swine model of coronary artery disease.
Does a low-dose, single-volume quantitative CT technique accurately measure myocardial flow compared to reference standards in phantom and swine models?
Comparison
Single-volume quantitative CT flow technique vs ultrasound and microsphere reference measurements
Design
Phantom and animal validation study
Authors
Loading...
Supports preclinical validation of low-dose CT myocardial flow; leaves open human translation in coronary disease.
Does a low-dose, single-volume quantitative CT technique accurately measure myocardial flow compared to reference standards in phantom and swine models?
Effect estimate: Pearson's r = 0.96
A low-dose, single-volume quantitative CT technique accurately measures myocardial flow under rest and stress conditions in phantom and swine models.
Hubbard et al. (2023) studied coronary artery disease (n=6). Low-dose single-volume quantitative CT myocardial flow measurement vs. Ultrasound and microsphere flow was evaluated on Correlation between quantitative CT flow and reference flow measurements (Pearson's r = 0.96). Low-dose single-volume quantitative CT myocardial flow measurement accurately correlated with reference microsphere flow in a swine model (Pearson's r = 0.96) and ultrasound in a phantom (r = 0.98).