Key result
Male carriers of the NOS1AP rs164148 AA genotype had a significantly shorter QTc interval compared to GG carriers during methadone treatment (405.9 vs 423 ms, p=0.016).
Why the study?
Methadone-induced severe QTc prolongation appears unpredictable and sex-dependent, and common NOS1AP variants may interact with methadone in patients with heroin dependence.
Does the NOS1AP rs164148 AA genotype variant attenuate QTc prolongation in heroin-dependent men undergoing methadone treatment?
Population
Patients with heroin dependence across two cohorts (122 in Cohort 1 and 319 in Cohort 2)
Comparison
17 NOS1AP variants spanning the entire gene
Design
Two-cohort genetic association study
Authors
Loading...
NOS1AP genotyping may identify lower-risk men on methadone; leaves open whether variants should guide therapy or monitoring.
Cohort (n=441)
Does the NOS1AP rs164148 AA genotype variant attenuate QTc prolongation in heroin-dependent men undergoing methadone treatment?
Absolute Event Rate: 405.9% vs 423%
p-value: p=0.016
The NOS1AP rs164148 AA genotype is associated with a shorter QTc interval in men on methadone, suggesting a genetic basis for the heterogeneous risk of methadone-induced QTc prolongation.
Chang et al. (2022) conducted a cohort in Heroin dependence undergoing methadone treatment (n=441). NOS1AP rs164148 AA genotype vs. NOS1AP rs164148 GG genotype was evaluated on QTc interval (p=0.016). Male carriers of the NOS1AP rs164148 AA genotype had a significantly shorter QTc interval compared to GG carriers during methadone treatment (405.9 vs 423 ms, p=0.016).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: