Associations between NOS1AP Single Nucleotide Polymorphisms (SNPs) and QT Interval Duration in Four Racial/Ethnic Groups in the Multi‐Ethnic Study of Atherosclerosis (MESA)
Why the study?
Are NOS1AP single nucleotide polymorphisms associated with QT interval duration across different racial and ethnic groups?
Population
2847 participants from the Multi-Ethnic Study of Atherosclerosis, age 45-84 years, without cardiovascular…
Comparison
28 tagging SNPs spanning the NOS1AP gene vs Alternative alleles
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Ancestry-specific NOS1AP-QT associations are hypothesis-generating; leaves open validation for ancestry-adjusted arrhythmia risk models.
Structured PICO
Are NOS1AP single nucleotide polymorphisms associated with QT interval duration across different racial and ethnic groups?
P
Population
2847 participants from the Multi-Ethnic Study of Atherosclerosis (MESA), age 45-84 years, without cardiovascular disease, comprising approximately equal numbers of Caucasians (CAU), African Americans (AFA), Hispanics (HIS), and Chinese (CHN).
I
Intervention
28 tagging SNPs spanning the NOS1AP gene
C
Comparator
Alternative alleles (evaluated using an additive inheritance model)
O
Outcome
QT interval duration measured using 12-lead ECGsurrogate
Genetic associations between NOS1AP variants and QT interval duration exhibit significant heterogeneity in specific SNP locations across different racial and ethnic groups.
Cite This Study
Shah et al. (2013) studied this question.