January 31, 2008DiabetesOpen Access

Association of NOS1AP Genetic Variants With QT Interval Duration in Families From the Diabetes Heart Study

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Why the study?

Are NOS1AP genetic variants associated with prolonged QT interval duration in a type 2 diabetes-enriched population?

Structured PICO

Are NOS1AP genetic variants associated with prolonged QT interval duration in a type 2 diabetes-enriched population?

Population

751 individuals (624 European Americans, 127 African Americans) from 400 pedigrees enriched for type 2 diabetes, excluding individuals taking QT-altering medications.

Intervention

NOS1AP genetic variants (rs10494366 and rs10918594 minor homozygotes)

Comparator

Major homozygotes for the respective NOS1AP SNPs

Outcome

QT interval durationsurrogate

Limitations

Limited number of African Americans to observe an association

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

NOS1AP variant may prolong QT in diabetic European Americans; leaves open replication and any role for genotyping in arrhythmia risk assessment.

Cite This Study

Lehtinen et al. (2008) studied this question.

synapsesocial.com/papers/6a0fcb7bd12fb77703193c93 https://doi.org/10.2337/db07-1365

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Implication

NOS1AP variant may prolong QT in diabetic European Americans; leaves open replication and any role for genotyping in arrhythmia risk assessment.

Association of NOS1AP Genetic Variants With QT Interval Duration in Families From the Diabetes Heart Study

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Association of NOS1AP Genetic Variants With QT Interval Duration in Families From the Diabetes Heart Study

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

Also Consider