Key result
NOS1AP genetic variants are linked to a ~6 ms difference in adjusted QT interval.
Why the study?
An association of the electrocardiographic QT interval with polymorphisms in the NOS1AP gene was discovered through a genome-wide association study and required replication in the Old Order Amish.
Are genetic variants in the NOS1AP gene associated with variations in the QT interval in the Old Order Amish?
Observational (n=763)
Are genetic variants in the NOS1AP gene associated with variations in the QT interval in the Old Order Amish?
Mean Difference: 6.1
p-value: p=0.006
Variants in the NOS1AP gene are significantly associated with QT interval duration, replicating previous genome-wide association study findings.
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Supports modest NOS1AP effect on QT in Amish; confirms GWAS replication but leaves clinical relevance open.
Post et al. (2007) conducted an observational in QT interval variation (n=763). NOS1AP (CAPON) gene variants was evaluated on Adjusted QT interval (average genetic effect of 6.1 ms, p=0.006). NOS1AP genetic variants were significantly associated with variation in adjusted QT interval, with SNP rs10494366 having an average genetic effect of 6.1 ms (p=0.006).
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