Key result
Common genetic variants near the NOS1AP and PLN genes are significantly associated with QT interval duration, explaining 0.82% and 0.74% of the variance, respectively.
Population
3,558 subjects from 3 cohorts in the UK and North America. TwinsUK, BRIGHT, DCCT/EDIC. Exclusions: ischemic…
Design
Meta-analysis
Authors
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Small effect sizes limit immediate clinical use for arrhythmia risk; extends GWAS evidence on repolarization genetics.
Meta-Analysis (n=3,558)
Yes
Effect estimate: 0.82% variance explained (rs12143842)
p-value: p=1.4x10^-283
Common genetic variants near the phospholamban (PLN) and NOS1AP genes are significantly associated with QT interval duration, providing mechanistic insights into genetic influences on cardiac repolarization.
Nolte et al. (2009) conducted a meta-analysis in QT interval duration (cardiac repolarisation) (n=3,558). Common genetic variants near NOS1AP (rs12143842) and PLN (rs11153730) vs. Reference alleles was evaluated on QT interval duration (0.82% variance explained (rs12143842), p=1.4x10^-283). Common genetic variants near the NOS1AP and PLN genes are significantly associated with QT interval duration, explaining 0.82% and 0.74% of the variance, respectively.
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