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March 7, 2007HeartOpen Access

Syncope and QT prolongation among patients treated with methadone for heroin dependence in the city of Copenhagen

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Why the study?

Does methadone increase the risk of QT prolongation and syncope compared to buprenorphine in adult heroin addicts?

Population

450 adult heroin addicts treated with methadone or buprenorphine on a daily basis at the Drug Addiction…

Comparison

Methadone vs Buprenorphine

Design

Cross-sectional

Authors

SFSøren FanoeHvidovre HospitalCHChristian HvidtCopenhagen Municipal HospitalEPEge PCopenhagen Municipal Hospital

Discussion

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Implication

Supports QT monitoring with methadone; cross-sectional data leaves open whether buprenorphine is safer.

Structured PICO

Does methadone increase the risk of QT prolongation and syncope compared to buprenorphine in adult heroin addicts?

P
Population
450 adult heroin addicts treated with methadone or buprenorphine on a daily basis at the Drug Addiction Service in Copenhagen
I
Intervention
Methadone
C
Comparator
Buprenorphine
O
Outcome
QT interval prolongation and self-reported syncopesafety

Methadone, but not buprenorphine, is associated with dose-dependent QT prolongation and an increased risk of syncope in heroin addicts.

Cite This Study

Fanoe et al. (2007) studied this question.

synapsesocial.com/papers/6a8371d648656d5c51fae2e9https://doi.org/10.1136/hrt.2006.100180
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1QTc Interval Prolongation in Patients on Long-Term Methadone Maintenance Therapy2004 · 117 citations
  2. 2High dose methadone and ventricular arrhythmias: a report of three cases2003 · 103 citations
  3. 3QTc prolongation measured by standard 12-lead electrocardiography is an independent risk factor for sudden death due to cardiac arrest.1991 · 598 citations
  4. 4QTc interval prolongation associated with intravenous methadone2003 · 243 citations