Key result
Methadone therapy is associated with QTc interval prolongation, with the risk of severe arrhythmias like Torsade de Pointes being significantly increased by concurrent risk factors such as high doses, co-medication, and co-morbidities.
Why the study?
Does methadone treatment cause QTc interval prolongation in heroin addicts?
Population
Heroin addicts on methadone treatment
Design
Review
Authors
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May support ECG monitoring in methadone patients with risk factors; leaves open the need for prospective trials to guide practice.
Does methadone treatment cause QTc interval prolongation in heroin addicts?
Methadone treatment in heroin addicts is associated with QTc prolongation, necessitating risk factor screening and monitoring to prevent severe arrhythmias.
Jovanović et al. (2015) conducted a review in Heroin addiction / Opioid dependence. Methadone maintenance treatment was evaluated on QTc interval prolongation. Methadone therapy is associated with QTc interval prolongation, with the risk of severe arrhythmias like Torsade de Pointes being significantly increased by concurrent risk factors such as high doses, co-medication, and co-morbidities.
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