September 19, 2008Journal of Addictive Diseases

Heterogeneous Impact of Methadone on the QTc Interval: What Are the Practical Implications?

View Full Paper

Ask AI

Bookmark

Why the study?

Does methadone induction increase the QTc interval in heroin addicts?

Population

151 heroin addicts from a previously published prospective cohort study

Comparison

Methadone induction vs Baseline (before methadone induction)

Design

Cohort

Follow-up

6 months

Authors

MKMori J. KrantzAmerican College of Cardiology

Discussion

Member takes

Implication

Methadone induction was associated with QTc prolongation; leaves open whether routine ECG screening meaningfully alters outcomes in addiction care.

Structured PICO

Does methadone induction increase the QTc interval in heroin addicts?

Population

151 heroin addicts from a previously published prospective cohort study

Intervention

Methadone induction

Comparator

Baseline (before methadone induction)

Outcome

Change in QTc interval at 6 months, including absolute increases above categorical thresholds and proportion with increases exceeding 30 and 60 msecsurrogate

While methadone frequently causes QTc prolongation, critical increases (>500 msec or >60 msec increase) are infrequent, suggesting ECG screening would only occasionally require discontinuation.

Cite This Study

Mori J. Krantz (2008) studied this question.

synapsesocial.com/papers/6a8bd9a160c8c47a9ee3eca6 https://doi.org/10.1080/10550880802324317

View Full Paper

Ask AI

Bookmark

Implication

Methadone induction was associated with QTc prolongation; leaves open whether routine ECG screening meaningfully alters outcomes in addiction care.

Heterogeneous Impact of Methadone on the QTc Interval: What Are the Practical Implications?

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Heterogeneous Impact of Methadone on the QTc Interval: What Are the Practical Implications?

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider