Key result
Daily methadone dose correlated positively with the QTc interval (r = +0.51, p = 0.03) in patients who developed torsade de pointes, supporting its contribution to the arrhythmia.
Why the study?
Does the daily dose of methadone correlate with the degree of QTc prolongation in patients who develop torsade de pointes?
Population
17 patients who developed torsade de pointes while receiving very high daily doses of methadone
Design
Case_series
Authors
Loading...
Warrants QTc monitoring with higher methadone doses; leaves open causal confirmation in prospective studies.
Observational (n=17)
Yes
Does the daily dose of methadone correlate with the degree of QTc prolongation in patients who develop torsade de pointes?
Effect estimate: r = +0.51
p-value: p=0.03
In patients developing torsade de pointes on methadone, the daily dose of methadone positively correlates with the QTc interval, suggesting a dose-dependent proarrhythmic effect.
Krantz et al. (2003) conducted an observational in Torsade de pointes (n=17). Methadone was evaluated on Relationship between daily methadone dose and QTc interval (r = +0.51, p=0.03). Daily methadone dose correlated positively with the QTc interval (r = +0.51, p = 0.03) in patients who developed torsade de pointes, supporting its contribution to the arrhythmia.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: