March 1, 1977CirculationOpen Access

The effect of "ischemic" blood on transmembrane potentials of normal porcine ventricular myocardium.

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Why the study?

Does exposure to ischemic blood alter transmembrane potentials in normal porcine ventricular myocardium?

Population

Porcine ventricular myocardium muscle strips

Comparison

Exposure to 'ischemic' blood obtained from a… vs Exposure to control blood

Design

Preclinical

Authors

EDEugene DownarUniversity Health Network MJM J Janse DDD DurrerLeiden University

Discussion

Member takes

Implication

Unidentified factors in ischemic blood may depress myocardial excitability; leaves open their role in human ischemia-induced arrhythmias.

Structured PICO

Does exposure to ischemic blood alter transmembrane potentials in normal porcine ventricular myocardium?

Population

Porcine ventricular myocardium muscle strips

Intervention

Exposure to 'ischemic' blood obtained from a local coronary vein on release of coronary artery occlusion

Comparator

Exposure to control blood

Outcome

Changes in transmembrane potentials (action potential duration, resting potential, upstroke velocity, amplitude, refractoriness)surrogate

Ischemic blood contains unidentified factors that potently depress the excitability of normal myocardium, independent of known metabolic derangements.

Cite This Study

Downar et al. (1977) studied this question.

synapsesocial.com/papers/6a787777576efb0ddaf81ccf https://doi.org/10.1161/01.cir.55.3.455

View Full Paper

Ask AI

Bookmark

The effect of "ischemic" blood on transmembrane potentials of normal porcine ventricular myocardium.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The effect of "ischemic" blood on transmembrane potentials of normal porcine ventricular myocardium.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider