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March 1, 2019European Heart Journal SupplementsOpen Access

Cardiovascular magnetic resonance and endomyocardial biopsy improve diagnostic sensitivity, risk stratification, and enable etiology-directed treatment in patients with suspected myocarditis.

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Why the study?

Studies on myocarditis risk stratification and prognosis have lacked uniform conclusions, often due to a lack of diagnostic confirmation by endomyocardial biopsy.

Design

Review

Key result

Cardiovascular magnetic resonance and endomyocardial biopsy improve diagnostic sensitivity, risk stratification, and enable etiology-directed treatment in patients with suspected myocarditis.

Authors

ACAlida L.P. CaforioGeneral CardiologyCCChun‐Yan ChengChinese Academy of Medical Sciences & Peking Union Medical CollegeMMMartina Perazzolo MarraCardiac Imaging

Discussion

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Overview

Variable myocarditis presentations demand individualized care; leaves open standardized risk stratification pending diagnostic consensus.

Structured PICO

P
Population
Patients with clinically suspected or biopsy-proven myocarditis
I
Intervention
Cardiovascular magnetic resonance (CMR) and endomyocardial biopsy (EMB)

Cardiovascular magnetic resonance and endomyocardial biopsy are complementary diagnostic tools that improve the aetiological diagnosis and targeted therapy of myocarditis.

Limitations

  • Cardiac magnetic resonance does not allow to exclude myocardial infections and should not be considered the gold standard
  • Endomyocardial biopsy carries a risk of complications

Cite This Study

Caforio et al. (2019) conducted a review in Myocarditis. Cardiovascular magnetic resonance and endomyocardial biopsy was evaluated. Cardiovascular magnetic resonance and endomyocardial biopsy improve diagnostic sensitivity, risk stratification, and enable etiology-directed treatment in patients with suspected myocarditis.

synapsesocial.com/papers/6a787ce0137c7dcc81be77c1https://doi.org/10.1093/eurheartj/suz014
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiovascular Magnetic Resonance Assessment of Human Myocarditis2004 · 1,033 citations
  2. 2Performance of T1 and T2 Mapping Cardiovascular Magnetic Resonance to Detect Active Myocarditis in Patients With Recent-Onset Heart Failure2015 · 209 citations
  3. 3Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases2013 · 3,499 citations
  4. 4Cardiovascular Magnetic Resonance in Myocarditis: A JACC White Paper2009 · 2,525 citations
  5. 5Diagnostic synergy of non-invasive cardiovascular magnetic resonance and invasive endomyocardial biopsy in troponin-positive patients without coronary artery disease2009 · 241 citations