Key result
Peritoneal dialysis for 12 months was associated with decreased ET-1, increased NO (p<0.01), and significant reductions in left ventricular mass index and carotid intima media thickness (p<0.001).
Why the study?
Does 12 months of peritoneal dialysis treatment improve endothelial biomarkers and cardiovascular remodeling parameters in PD patients?
Observational (n=40)
Does 12 months of peritoneal dialysis treatment improve endothelial biomarkers and cardiovascular remodeling parameters in PD patients?
Peritoneal dialysis over 12 months is associated with improved endothelial biomarkers and reduced cardiovascular remodeling parameters such as LV mass index and carotid IMT.
May support cardiovascular benefits of peritoneal dialysis; hypothesis-generating and requires randomized confirmation before practice change.
OBJECTIVES: The purpose of this study was to determine endothelin (ET)-1 and nitric oxide (NO) serum concentration levels at baseline and after 1 year of peritoneal dialysis (PD) treatment. A further aim was to evaluate the association between ET-1 and NO with parameters of echocardiography and the common carotid artery (CCA) ultrasound, and to assess their impact on cardiovascular remodeling. We also aimed to evaluate the influence of dialysis adequacy and residual renal function (RRF) on cardiovascular remodeling. METHODS: This study included 40 PD patients in whom we measured serum ET-1 and NO concentrations, echocardiography and CCA ultrasound parameters. RESULTS: ET-1 decreased and NO serum concentration levels increased (p < 0.01) after 12 months of PD treatment compared to baseline values. Left ventricular (LV) hypertrophy was observed in 77.5% of patients at baseline with significant reduction in LV mass index (LVMI), CCA intima media thickness (IMT) and plaque score after 12 months of PD treatment (p < 0.001). The dialysis adequacy and RRF were significantly associated with LVMI and CCA IMT after 12 months on PD. CONCLUSION: In our study, ET-1 significantly decreased while NO increased during PD treatment and both were independently related to the cardiovascular remodeling parameters in PD patients.
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Rebić et al. (2014) conducted an observational in Peritoneal dialysis (n=40). Peritoneal dialysis vs. Baseline was evaluated on Serum ET-1 and NO concentrations, and cardiovascular remodeling parameters (p=<0.01). Peritoneal dialysis for 12 months was associated with decreased ET-1, increased NO (p<0.01), and significant reductions in left ventricular mass index and carotid intima media thickness (p<0.001).
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