Why the study?
In chronic kidney disease, endothelin-1 levels increase and cardiac ultrasonography changes occur, but the predictive role of serum ET-1 for cardiac complications is unclear.
Does serum ET-1 level correlate with echocardiographic indices of left ventricular remodeling in non-dialysis patients with chronic kidney disease?
Observational
Does serum ET-1 level correlate with echocardiographic indices of left ventricular remodeling in non-dialysis patients with chronic kidney disease?
p-value: p=<.001
Serum ET-1 levels correlate with echocardiographic indices of left ventricular remodeling in non-dialysis CKD patients, suggesting its potential as a biomarker for cardiac complications.
Supports ET-1 as potential biomarker for LV remodeling in CKD; hypothesis-generating and should not yet change practice.
BACKGROUND: In chronic kidney disease (CKD), endothelin-1 (ET-1) always increases and there are changes in cardiac ultrasonography. In the present study, we aimed at investigating the role of serum ET-1 in predicting cardiac complications in patients with CKD. METHODS: The level of serum ET-1 was measured by enzyme-linked immunosorbent assay (ELISA) and cardiac ultrasonography was performed in enrolled patients. Indexes of heart failure, such as left ventricular mass index, interventricular septum thickness and left ventricular end diastolic diameter, were measured in patients with CKD. RESULTS: In the present study, we found that the level of serum ET-1 was significantly correlated with left ventricular mass index, interventricular septum thickness and left ventricular end diastolic diameter (p < .001) in non-dialysis patients with CKD. CONCLUSIONS: The results of the present study indicated that the level of serum ET-1 is closely related to the cardiac complications of CKD and is a useful predictor of cardiac complication.
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Peng et al. (2018) conducted an observational in Chronic kidney disease. Serum endothelin-1 (ET-1) was evaluated on Correlation with left ventricular mass index, interventricular septum thickness and left ventricular end diastolic diameter (p=<.001).
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