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Endothelin-1 as dual marker for renal function decline and associated cardiovascular complications in patients with chronic kidney disease

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Observational analysis reveals endothelin-1 predicts renal decline and cardiovascular events in CKD patients, suggesting its clinical relevance.

Higher endothelin-1 levels were significantly linked to accelerated decline in eGFR over three years.
Increased endothelin-1 concentrations were associated with lower cardiovascular event-free survival in CKD patients.
Findings indicate that endothelin-1 could serve as a dual marker for kidney function and cardiovascular risk.
The study involved 692 CKD patients with follow-up assessments over approximately 48.6 months.

González-Rodríguez et al. (2025) studied this question.

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Observational analysis reveals endothelin-1 predicts renal decline and cardiovascular events in CKD patients, suggesting its clinical relevance.