Why the study?
Are elevated plasma endothelin levels associated with cardiovascular remodeling in patients with end-stage renal disease?
Population
76 haemodialysis patients with end-stage renal disease and 57 age-, sex-, and blood pressure-matched controls
Design
Cross-sectional
Authors
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Elevated ET levels associate with LV mass and IMT in ESRD; hypothesis-generating for remodeling but requires prospective confirmation before clinical implications.
Are elevated plasma endothelin levels associated with cardiovascular remodeling in patients with end-stage renal disease?
Elevated plasma endothelin levels in end-stage renal disease are independently associated with left ventricular hypertrophy and arterial intima-media thickening, suggesting a pathophysiological role in cardiovascular remodeling.
Demuth et al. (1998) studied this question.
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