Key result
Matrine suppressed viral RNA copy number in vitro and reduced mortality and relieved clinical symptoms in mice challenged with a lethal dose of enterovirus 71.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for matrine against EV71; leaves open human efficacy and should not change practice.
Human enterovirus 71, a member of the Picornaviridae family, is one of the major causative agent of hand, foot and mouth disease in children less than six years old. This illness has caused mortalities in large-scale outbreaks in the Asia-Pacific region in recent years. No vaccine or antiviral therapy is available. In this study, antiviral effect of matrine against enterovirus 71 were evaluated in vitro and in vivo. Matrine could suppress the viral RNA copy number on rhabdomyosarcoma cells. Moreover, matrine treatment of mice challenged with a lethal dose of enterovirus 71 reduced the mortality and relieved clinical symptoms. The results showed that matrine may represent a potential therapeutic agent for enterovirus 71 infection.
No takes yet. Share an insight, caveat, or question.
Yang et al. (2012) studied Human enterovirus 71 infection. Matrine was evaluated on Viral RNA copy number (in vitro) and mortality/clinical symptoms (in vivo). Matrine suppressed viral RNA copy number in vitro and reduced mortality and relieved clinical symptoms in mice challenged with a lethal dose of enterovirus 71.
Synapse has enriched 10 related papers. Consider them for comparative context: