Key result
An intensive 52-week dietary weight loss program in obese individuals significantly increased plasma NT-proBNP concentrations by a mean difference of 38 pg/mL compared to control.
Why the study?
Does an intensive weight reduction programme alter plasma concentrations of natriuretic peptides (NT-proBNP, MR-proANP, MR-proADM) in healthy obese subjects?
RCT (n=52)
Open-label with blinded endpoint assessment
Randomized
No
Does an intensive weight reduction programme alter plasma concentrations of natriuretic peptides (NT-proBNP, MR-proANP, MR-proADM) in healthy obese subjects?
Mean Difference: -38 (95% CI -61–-14)
Absolute Event Rate: 42% vs 4%
p-value: p=0.002
Substantial dietary-induced weight loss in obese individuals without heart disease leads to significant increases in plasma NT-proBNP and MR-proANP, highlighting the confounding effect of BMI and glucose metabolism on these cardiovascular biomarkers.
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Rising NT-proBNP during weight loss may confound interpretation in obese patients; confirms BMI and glucose metabolism as key confounders.
Kistorp et al. (2014) conducted an RCT in Obesity (n=52). Intensive weight reduction programme vs. Diet-related counselling (1200 kcal/day) was evaluated on Change in plasma NT-proBNP concentration at 52 weeks (MD -38 pg/mL, 95% CI -61 to -14, p=0.002). An intensive 52-week dietary weight loss program in obese individuals significantly increased plasma NT-proBNP concentrations by a mean difference of 38 pg/mL compared to control.
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