Key result
A 38-year-old male with metastatic lung cancer developed severe intracranial venous and mesenteric vein thrombosis, highlighting the critical need for optimal thromboprophylaxis and early diagnosis of venous thromboembolism in high-risk cancer patients.
Why the study?
Venous thromboembolism is a leading cause of death in cancer patients, yet oncologists may not place enough importance on prevention, highlighting clinical management dilemmas.
Case Report (n=1)
This case highlights the clinical dilemma and importance of balancing venous thromboembolism prophylaxis with bleeding risks in advanced cancer patients receiving targeted therapies.
Answers are grounded in this paper and cite their sources.
Illustrates severe VTE complications in advanced lung cancer with metastases; hypothesis-generating for tailored prophylaxis trials.
Cancer patients with venous thromboembolism (VTE) are not rare, and the second death cause in patients with cancer is VTE. Although VTE itself is associated with reduced survival particularly in cancer patients, many oncologists may not place enough importance in positive prevention of VTE. Here, we report the case of a 38-year-old male lung cancer patient with brain, bone and leptomeningeal metastasis who diagnosed as a consequential intracranial venous and mesenteric vein thrombosis. The evolution of headache has not been noted gradually, from which led to the underestimation of headache and without careful consideration on the possibility of suspected intracranial venous thrombosis. The problem of mesenteric vein thrombosis reflects the dilemma resulted from the potential risk of thrombogenesis and the high risk of hemorrhage. Preventive anticoagulation strategies are key means especially in patients with cancer, and the management problems of this condition are discussed.
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Shen et al. (2019) conducted a case report in Lung cancer with brain, bone, and leptomeningeal metastasis complicated by venous thromboembolism (n=1). Low-molecular-weight heparin and antineoplastic therapies was evaluated on Clinical outcome and overall survival. A 38-year-old male with metastatic lung cancer developed severe intracranial venous and mesenteric vein thrombosis, highlighting the critical need for optimal thromboprophylaxis and early diagnosis of venous thromboembolism in high-risk cancer patients.
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