What question did this study set out to answer?

To re-evaluate the etiology, histopathologic features, and clinical manifestations of bone marrow necrosis in biopsy specimens.

July 26, 2002American Journal of HematologyOpen Access

Bone marrow necrosis: Clinicopathologic analysis of 20 cases and review of the literature

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To re-evaluate the etiology, histopathologic features, and clinical manifestations of bone marrow necrosis in biopsy specimens.
Retrospectively reviewed 1,083 bone marrow biopsies performed over an 8-year period.
Evaluated 20 adult cases of bone marrow necrosis for underlying etiology, clinical presentation, laboratory findings, and histopathologic grading of necrosis and reticulin fibrosis.
Bone marrow necrosis was identified in 2.2% of biopsies (23/1,083), with adult cases driven by malignant disease in 80% (16/20) and nonmalignant conditions in 20% (4/20).
Histopathologic analysis showed extensive necrosis in 12 cases and increased reticulin fibrosis in 16 cases (4 severe, 8 moderate, 4 mild).
Common clinical manifestations included bone pain, fever, fatigue, cytopenias, and elevated levels of lactate dehydrogenase and alkaline phosphatase.

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Implication

Retrospective analysis reveals hematopoietic malignancies and reticulin fibrosis as predominant features in bone marrow necrosis, highlighting the need to evaluate nonmalignant causes.

Cite This Study

Paydaş et al. (2002) studied this question.

synapsesocial.com/papers/6a788edd729b6f60311eb28f https://doi.org/10.1002/ajh.10114

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Implication

Retrospective analysis reveals hematopoietic malignancies and reticulin fibrosis as predominant features in bone marrow necrosis, highlighting the need to evaluate nonmalignant causes.

Bone marrow necrosis: Clinicopathologic analysis of 20 cases and review of the literature

Key Points

Discussion

Implication

Cite This Study

Bone marrow necrosis: Clinicopathologic analysis of 20 cases and review of the literature

Key Points

Discussion

Implication

Cite This Study

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