Influence of aging on left ventricular hemodynamics and stiffness in beagles.
Why the study?
Does aging increase left ventricular stiffness and contraction duration in beagles?
Population
29 beagles
Comparison
Old age (mean 128 +/- 20.5 months) vs Young age (mean 27 +/- 2.5 months)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May model age-related LV stiffening in canines; leaves open translation to human diastolic dysfunction.
Structured PICO
Does aging increase left ventricular stiffness and contraction duration in beagles?
P
Population
29 beagles (15 in complete cardiopulmonary bypass experiment: 8 young [mean age 27 +/- 2.5 months] and 7 old [mean age 128 +/- 20.5 months]; 14 in right heart bypass experiment: 7 young and 7 old)
I
Intervention
Old age (mean 128 +/- 20.5 months)
C
Comparator
Young age (mean 27 +/- 2.5 months)
O
Outcome
Left ventricular contractile performance, stiffness, and contraction timesurrogate
Aging in the canine model is associated with increased left ventricular systolic and diastolic stiffness and prolonged contraction duration.
Cite This Study
Templeton et al. (1979) studied this question.