Key result
Older healthy Beagles exhibited significantly higher systolic, mean, and diastolic pulmonary arterial pressures compared to young dogs, driven by increased pulmonary vascular resistance and decreased compliance.
Why the study?
Does older age increase pulmonary arterial pressure and alter right ventricular diastolic function in healthy Beagles?
Cross-Sectional (n=14)
Single-blind
No
Does older age increase pulmonary arterial pressure and alter right ventricular diastolic function in healthy Beagles?
In healthy Beagles, older age is associated with increased pulmonary arterial pressure due to higher pulmonary vascular resistance and lower compliance, which should be considered when interpreting hemodynamic and echocardiographic results.
Answers are grounded in this paper and cite their sources.
Age must be considered in canine pulmonary pressure norms; leaves open translation to human right-heart aging and requires prospective studies.
OBJECTIVE: To assess the influence of age on pulmonary hemodynamics and hemorheological properties in healthy dogs. ANIMALS: 14 healthy Beagles. PROCEDURES: Dogs were placed in 2 age groups as follows: young dogs (<or= 5 years old; n = 8) and old dogs (>or= 8 years old; 6). Hematologic characteristics, plasma total protein and fibrinogen concentrations, and blood viscosity were measured. Systolic time intervals of pulmonary blood flow were recorded by pulsed-wave Doppler echocardiography. Early (E') and late (A') diastolic myocardial velocities, isovolumic contraction velocity, and systolic myocardial velocity of the free tricuspid annulus were recorded by pulsed-wave tissue Doppler imaging (TDI). Dogs were anesthetized and pulmonary arterial pressures (PAP) and cardiac output were recorded with a pediatric thermodilution Swan-Ganz catheter. RESULTS: Hemorheological measurements were not different between the 2 groups. Systolic, mean, and diastolic PAP were higher in old dogs, compared with values in young dogs; this difference was attributed to a high pulmonary vascular resistance and low arterial compliance in old dogs. Systolic time intervals of pulmonary blood flow stayed unchanged. The A' wave of the free tricuspid annulus was increased in old, compared with that young dogs, and the E':A' ratio was decreased. Pulmonary vascular resistance was inversely correlated with compliance. CONCLUSIONS AND CLINICAL RELEVANCE: The age of dogs should be taken into account when interpreting pulmonary hemodynamic results and TDI variables of right ventricular diastolic function.
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Mercier et al. (2010) conducted a cross-sectional in Healthy (n=14). Advanced age (≥ 8 years) vs. Young age (≤ 5 years) was evaluated on Systolic pulmonary arterial pressure (sPAP) in mm Hg (p=0.003). Older healthy Beagles exhibited significantly higher systolic, mean, and diastolic pulmonary arterial pressures compared to young dogs, driven by increased pulmonary vascular resistance and decreased compliance.
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