Key result
The C-terminal tail of sarcolipin is an essential domain for SERCA regulation, and its functional properties can be transferred to phospholamban.
Population
Co-reconstituted proteoliposomes of sarco(endo)plasmic reticulum calcium ATPase (SERCA) and sarcolipin (SLN)
Comparison
Alanine mutants of the C-terminal tail of SLN… vs Wild-type SLN and PLN
Design
Preclinical
Authors
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Does not support clinical changes in SERCA-related therapies; leaves open whether SLN C-terminal transfer to PLN holds in mammalian models.
The C-terminal tail of SLN is a distinct, essential domain in the regulation of SERCA, and its functional properties can be transferred to PLN.
Gorski et al. (2013) studied this question. Alanine mutants of the C-terminal tail of SLN and PLN chimeras vs. Wild-type SLN and PLN was evaluated on SERCA regulatory function. The C-terminal tail of sarcolipin is an essential domain for SERCA regulation, and its functional properties can be transferred to phospholamban.
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