Construction of the amide/peptide bond is one of the most encountered transformations in the pharmaceutical and chemical industries. Traditional protocols rely on the use of undesirable organic solvents, such as N,N -dimethylformamide (DMF), N -methyl pyrrolidone (NMP), or dichloromethane (CH 2 Cl 2 ). These solvents adversely impact the environment, workers’ safety, and health. This has led academia and industry to search and develop greener and more sustainable amide forming synthetic protocols to increase performance in terms of yield and selectivity and avoid or reduce the dependency in these hazardous solvents. The following account discusses the recent development of amide/peptide bond formation in water.
No takes yet. Share an insight, caveat, or question.
Hazra et al. (2022) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: