Key result
CD/IGS rats treated with isoproterenol had higher and earlier mortality, and greater cardiac troponin I and T concentrations compared with Sasco or Harlan rats.
Population
Three outbred stocks of Sprague Dawley rats (CD/IGS, Sasco, Harlan)
Comparison
Isoproterenol hydrochloride vs Comparison among the three stocks
Design
Preclinical
Authors
Loading...
Rat stock variability may alter isoproterenol cardiotoxicity readouts; leaves open optimal strain selection for reproducible preclinical studies.
Significant differences exist in mortality and cardiac biomarker responses to cardiotoxicants among different stocks of Sprague Dawley rats, which must be accounted for in preclinical studies.
Schultze et al. (2011) studied Isoproterenol-induced cardiac injury. Isoproterenol hydrochloride vs. Comparison between rat stocks (CD/IGS vs Sasco vs Harlan) was evaluated on Mortality and cardiac biomarker responses. CD/IGS rats treated with isoproterenol had higher and earlier mortality, and greater cardiac troponin I and T concentrations compared with Sasco or Harlan rats.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: