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August 21, 2009Toxicologic Pathology

Longitudinal Studies of Cardiac Troponin-I Concentrations in Serum from Male Sprague Dawley Rats: Baseline Reference Ranges and Effects of Handling and Placebo Dosing on Biological Variability

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Key result

In male Sprague Dawley rats, the baseline reference range for cardiac troponin-I was 1-15 pg/mL (mean 4.94 pg/mL), showing minimal biological variability over 24 hours under standard handling.

Population

Male Sprague Dawley rats

Design

Preclinical

Follow-up

24 hours to long periods

Authors

ASA. Eric SchultzeEli Lilly (United States)KCKent H. CarpenterEli Lilly (United States)FWFrank H. WiansTexas Tech University

Discussion

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Implication

Establishes cTnI baselines in rats; leaves open validation for human cardiotoxicity models.

Structured PICO

P
Population
Healthy male Sprague Dawley rats evaluated for baseline cardiac troponin-I concentrations and biological variability over a 24-hour interval.
E
Exposure
Handling and placebo dosing under standard laboratory conditions
O
Outcome
Baseline reference ranges and biological variability of cardiac troponin-I (cTnI) concentrationsurrogate

Establishes baseline reference ranges and biological variability for cTnI in rats, providing a foundation for preclinical cardiotoxicity testing in drug development.

Cite This Study

Schultze et al. (2009) studied Healthy laboratory rats. Handling and placebo dosing was evaluated on Baseline cTnI concentration (95% CI 1-15). In male Sprague Dawley rats, the baseline reference range for cardiac troponin-I was 1-15 pg/mL (mean 4.94 pg/mL), showing minimal biological variability over 24 hours under standard handling.

synapsesocial.com/papers/6a78b6392e130d02afed4763https://doi.org/10.1177/0192623309343777
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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  5. 5Characterization of Troponin Responses in Isoproterenol-Induced Cardiac Injury in the Hanover Wistar Rat2007 · 75 citations