October 1, 1991AJP Heart and Circulatory Physiology
Capillary growth and geometry during long-term hypertension and myocardial hypertrophy in dogs
Population
15 mongrel dogs (8 with long-term renovascular hypertension and 7 control dogs)
Comparison
Long-term renovascular hypertension inducing… vs Control dogs
Design
Preclinical
Follow-up
7 months
Authors
Discussion
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Implication
Supports compensatory angiogenesis in experimental LVH; hypothesis-generating and leaves open human relevance or therapeutic targeting.
Structured PICO
P
Population
15 mongrel dogs (8 with long-term (7 months) renovascular hypertension (one-kidney, one-clip) and 7 control dogs)
I
Intervention
Long-term (7 months) renovascular hypertension (one-kidney, one-clip) inducing left ventricular hypertrophy
C
Comparator
Control dogs
O
Outcome
Angiogenic response of the myocardial capillary bed (including capillary length density, cross-sectional cardiocyte area, and total capillary length)surrogate
In a canine model of long-term hypertension, myocardial hypertrophy is accompanied by significant new capillary growth that partially compensates for increased left ventricular mass.
Cite This Study
Tomanek et al. (1991) studied this question.