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Urinary concentrations of metabolic products associated with neoplasms can change the supersaturation and thus alter the potential of crystal formation in urine. This study examines the ability of the BONN-Risk-Index (BRI)-method of induced crystallization of Ca-oxalate in urine for monitoring the progression of (uro-)oncological diseases. BRI was compared to tumor marker concentrations and imaging in patients with prostate cancer (PC) and patients with neuroendocrine tumors (NET). In NET, a correlation between BRI and the amount of bone metastases emerges. In PC, log2(BRI) and bone-specific alkaline-phosphatase inversely correlate with r = 0.71. It was shown that BRI and the clinical picture promisingly correlate.
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Laube et al. (2023) studied this question.
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