Key result
Haplotypes in the UTS2 gene region were significantly associated with fasting glucose values (p=0.008), while haplotypes in the adjacent PER3 gene were associated with fasting insulin (p=0.0047).
Why the study?
Do genetic variants in the UTS2 gene and flanking regions associate with biochemical parameters of insulin resistance in a Caucasian population?
Cross-Sectional (n=801)
Do genetic variants in the UTS2 gene and flanking regions associate with biochemical parameters of insulin resistance in a Caucasian population?
Polymorphisms in the UTS2 and PER3 genes are associated with glucose homeostasis and insulin resistance in a Caucasian population, supporting a genetic link to metabolic syndrome.
Hypothesis-generating for UTS2/PER3 variants in insulin resistance; should not yet change practice.
BACKGROUND: Urotensin II (UII) is a potent vasoconstrictor peptide, which signals through a G-protein coupled receptor (GPCR) known as GPR14 or urotensin receptor (UTR). UII exerts a broad spectrum of actions in several systems such as vascular cell, heart muscle or pancreas, where it inhibits insulin release. OBJECTIVE: Given the reported role of UII in insulin secretion, we have performed a genetic association analysis of the UTS2 gene and flanking regions with biochemical parameters related to insulin resistance (fasting glucose, glucose 2 hours after a glucose overload, fasting insulin and insulin resistance estimated as HOMA). RESULTS AND CONCLUSIONS: We have identified several polymorphisms associated with the analysed clinical traits, not only at the UTS2 gene, but also in thePER3 gene, located upstream from UTS2. Our results are compatible with a role for UII in glucose homeostasis and diabetes although we cannot rule out the possibility that PER3 gene may underlie the reported associations.
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Sáez et al. (2011) conducted a cross-sectional in Insulin Resistance (n=801). UTS2 and PER3 gene polymorphisms vs. Reference alleles/haplotypes was evaluated on Biochemical parameters related to insulin resistance (fasting glucose, 2h-glucose, fasting insulin, and HOMA). Haplotypes in the UTS2 gene region were significantly associated with fasting glucose values (p=0.008), while haplotypes in the adjacent PER3 gene were associated with fasting insulin (p=0.0047).
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