Key result
SonR demonstrated high concordance with Doppler echocardiography for timing of mitral and aortic valve closures, and systolic and diastolic intervals.
Why the study?
Does an automated system based on sonR accurately measure cardiac time intervals compared to Doppler echocardiography in recipients of CRT systems?
Observational (n=75)
Does an automated system based on sonR accurately measure cardiac time intervals compared to Doppler echocardiography in recipients of CRT systems?
Answers are grounded in this paper and cite their sources.
The sonR endocardial acceleration sensor demonstrates high concordance with Doppler echocardiography for measuring cardiac time intervals, suggesting it could be used to adaptively optimize CRT systems.
AIMS: Optimization of cardiac resynchronization therapy (CRT) requires the gathering of cardiac functional information. An accurate timing of the phases of the cardiac cycle is key in the optimization process. METHODS AND RESULTS: We compared Doppler echocardiography to an automated system, based on the recording of sonR (formerly endocardial acceleration), in the detection of mitral and aortic valves closures and measurements of the duration of systole and diastole. We prospectively studied, under various conditions of cardiac stimulation, 75 recipients of CRT systems (69% men), whose mean age was 72 ± 9.2 years, left ventricular ejection fraction 35 ± 11%, baseline QRS duration 154 ± 29 ms, and New York Heart Association functional class 3.0 ± 0.7. We simultaneously recorded (i) sonR, detected by a non-invasive piezoelectric micro-accelerometer sensor clipped onto an electrode located in the parasternal region, (b) electrocardiogram, and (c) Doppler audio signals, using a multichannel data acquisition and analysis system. The correlation between timing of mitral and aortic valve closure by sonR vs. Doppler signals was examined by linear regression analysis. Correlation coefficients and the average absolute error were calculated. A concordance in the timing of the mitral (r = 0.86, error = 9.7 ms) and aortic (r = 0.93, error = 9.7 ms) valves closure was observed between the two methods in 94% of patients. Similarly, sonR and the Doppler-derived measurements of systolic (r = 0.85, error = 13.4 ms) and diastolic (r = 0.99, error = 12 ms) interval durations were concordant in 80% of patients. CONCLUSION: A high concordance was found between sonR and the cardiac ultrasound in the timings of aortic and mitral valve closures and in the estimation of systolic and diastolic intervals durations. These observations suggest that sonR could be used to monitor cardiac function and adaptively optimize CRT systems.
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Donal et al. (2011) conducted an observational in Cardiac resynchronization therapy (CRT) recipients (n=75). sonR (endocardial acceleration) vs. Doppler echocardiography was evaluated on Concordance in the timing of mitral and aortic valve closures and systolic and diastolic interval durations. SonR demonstrated high concordance with Doppler echocardiography for timing of mitral and aortic valve closures, and systolic and diastolic intervals.
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