Population
Dictyostelium cells and purified recombinant myosin II protein
Comparison
Recombinant myosin II heavy chain lacking the… vs Wild-type myosin II heavy chain
Design
Preclinical
Authors
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Challenges assumption RLC binding is essential for myosin function; leaves open its role in mammalian cardiac contractility.
The regulatory light chain and its binding site on the myosin II heavy chain play an inhibitory role in ATPase activity and a structural role in actin movement, but are not strictly required for cytokinesis and development in Dictyostelium.
Uyeda et al. (1993) studied this question.
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