Key result
The proposed two-electrode, double-pulsed sensor readout circuit for Cardiac Troponin I measurement achieved a sensitivity of 1.77 Hz/pg-mL and a dynamic range of 72.43 dB.
A novel CMOS-based sensor readout circuit demonstrates high sensitivity and dynamic range for detecting Cardiac Troponin I in vitro.
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May enable compact troponin sensing circuits; leaves open clinical validation before diagnostic use.
This paper presents a pulse-stimulus sensor readout circuit for use in cardiovascular disease examinations. The sensor is based on a gold nanoparticle plate with an antibody post-modification. The proposed system utilizes gated pulses to detect the biomarker Cardiac Troponin I in an ionic solution. The characteristic of the electrostatic double-layer capacitor generated by the analyte is related to the concentration of Cardiac Troponin I in the solvent. After sensing by the transistor, a current-to-frequency converter (I-to-F) and delay-line-based time-to-digital converter (TDC) convert the information into a series of digital codes for further analysis. The design is fabricated in a 0.18-μm standard CMOS process. The chip occupies an area of 0.92 mm2and consumes 125 μW. In the measurements, the proposed circuit achieved a 1.77 Hz/pg-mL sensitivity and 72.43 dB dynamic range.
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Shan et al. (2020) studied Cardiovascular disease. Two-Electrode, Double-Pulsed Sensor Readout Circuit was evaluated on Sensitivity and dynamic range. The proposed two-electrode, double-pulsed sensor readout circuit for Cardiac Troponin I measurement achieved a sensitivity of 1.77 Hz/pg-mL and a dynamic range of 72.43 dB.
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