Serum Caveolin-1 Level is Inversely Associated with Serum Vaspin, Visfatin, and HbA1c in Newly Diagnosed Men with Type-2 Diabetes

Background:The fluctuation in serum caveolin-1 (Cav-1) concentrations is an important indicator of many diseases.Irrespective of the actual cause, a significant reduction of serum Cav-1 is associated with a significant increase in insulin secretion and hyperinsulinemia.The aim of the current study was to evaluate the relationship between serum Cav-1, serum vaspin and visfatin in newly diagnosed men with T2DM.Methods: Eighty-two newly diagnosed men with T2DM were matched for age and body mass indexes (BMIs) with a similar number of non-diabetic men.Serum Cav-1, vaspin and visfatin were assessed through enzyme-linked immunosorbent assay.Fasting serum glucose (FSG), glycohaemoglobin A1C (HbA1c) were both measured using automated method.In addition, waist-circumferences, waist-hip ratio, systolic (SBP), and diastolic blood pressure (DBP) were also obtained.Results: Serum concentration of Cav-1(ng/mL) was significantly low in men newly diagnosed with T2DM, (2.3340.7627)compared with non-diabetic controls (4.3211.143),p< 0.0001.In contrast, patients with T2DM exhibited significantly higher serum concentrations of vaspin and visfatin (ng/mL), 142.460.53)and 2.991.091),than controls, 81.5339.32)and 1.4560.654),respectively, p< 0.0001.Expectedly, patients with T2DM have significantly higher FSG, HbA1c, systolic blood pressure (SBP), and diastolic blood pressure (DBP).Conclusions: There was an inverse significant relationship between Cav-1 and vaspin, visfatin, HbA1c, FSG, and hypertension.This study suggests that serum Cav-1 can be used as a diagnostic marker to predict T2DM in individuals and families under high risk.