Key result
The G50C SNP in the goat LPL gene was suggestively associated with milk fat content and tended to affect milk dry weight basis, whereas the C2094T SNP showed no association with measured traits.
Observational (n=130)
The G50C polymorphism in the goat LPL gene may influence milk fat content.
Lipoprotein lipase (LPL) is a glycoprotein that plays a central role in plasma triglyceride metabolism by hydrolyzing triglyceride-rich chylomicrons and very low density lipoproteins. The activity of milk LPL has been shown to differ among several goat breeds, suggesting the existence of a genetic polymorphism influencing the functional properties of this enzyme. We have characterized the complete coding sequence of the goat LPL gene in 18 individuals belonging to 3 breeds. The coding region of the goat LPL cDNA was 1,437 bp long and encoded a protein of 478 amino acids. Moreover, we have identified 2 single nucleotide polymorphisms (SNP) including a G50C missense mutation, which involved a Ser-->Thr amino acid replacement at position 17 of the signal peptide, and a C2094T substitution in the 3' untranslated region. A univariate mixed model was used to evaluate the association between LPL genotypes and milk production and composition in 130 Murciano-Granadina goats. The G50C SNP was suggestively associated with milk fat content and tended to affect the milk dry weight basis. The C2094T SNP was not associated with any of the measured traits.
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Badaoui et al. (2007) conducted an observational in Milk production traits in goats (n=130). LPL genotypes (G50C and C2094T SNPs) was evaluated on Milk production and composition. The G50C SNP in the goat LPL gene was suggestively associated with milk fat content and tended to affect milk dry weight basis, whereas the C2094T SNP showed no association with measured traits.
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