Key result
All-cause mortality after elective ICD generator exchange was significantly higher in octogenarians compared to septuagenarians (79% vs 42.5%, P<0.01).
Why the study?
ICD therapy in elderly patients is controversial because survival benefits might be attenuated by nonarrhythmic causes of death, prompting investigation into outcomes after generator exchange in septuagenarians and octogenarians.
Does age (octogenarian vs septuagenarian) affect mortality and the incidence of appropriate ICD shocks after elective ICD generator exchange?
Cohort (n=506)
Does age (octogenarian vs septuagenarian) affect mortality and the incidence of appropriate ICD shocks after elective ICD generator exchange?
Absolute Event Rate: 79% vs 42.5%
p-value: p=<.01
Elderly patients, particularly octogenarians, undergoing ICD generator exchange have high all-cause mortality that frequently precedes appropriate ICD shocks, highlighting the need for individualized decision-making.
High post-GE mortality in octogenarians warrants individualized selection; leaves open net benefit of routine exchange in this population.
Background Implantable cardioverter-defibrillator (ICD) therapy in elderly patients is controversial because survival benefits might be attenuated by nonarrhythmic causes of death. Objective The purpose of this study was to investigate the outcome of septuagenarians and octogenarians after ICD generator exchange (GE). Methods A total of 506 patients undergoing elective GE were analyzed to determine the incidence of ICD shocks and/or survival after GE. Patients were divided into a septuagenarian group (age 70–79 years) and an octogenarian group (age ≥80 years). The primary endpoint was death from any cause. Secondary endpoints were survival after appropriate ICD shock and death without experiencing ICD shocks after GE ("prior death"). Results The association of the ICD with all-cause mortality and arrhythmic death was determined for septuagenarians and octogenarians. Comparing both groups, similar left ventricular ejection fraction (35.6% ± 11.2% vs 32.4% ± 8.9%) and baseline prevalence of New York Heart Association functional class III or IV heart failure (17.1% vs 14.7%) were found. During the entire follow-up period of the study, 42.5% of patients in the septuagenarian group died compared to 79% in the octogenarian group ( P <.01). Prior death was significantly more frequent in both age groups than were appropriate ICD shocks. Predictors of mortality were common in both groups and included advanced heart failure, peripheral arterial disease, and renal failure. Conclusion In clinical practice, decision-making for ICD GE among the elderly should be considered carefully for individual patients.
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Andresen et al. (2023) conducted a cohort in Elective ICD generator exchange (n=506). Age ≥80 years (octogenarians) vs. Age 70-79 years (septuagenarians) was evaluated on death from any cause (p=<.01). All-cause mortality after elective ICD generator exchange was significantly higher in octogenarians compared to septuagenarians (79% vs 42.5%, P<0.01).
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