May 1, 1998Cardiovascular ResearchOpen Access

Calcitonin gene-related peptide in myocardial ischaemia and reperfusion in the pig

View Full Paper

Ask AI

Bookmark

Why the study?

Does retroinfusion of CGRP reduce infarct size in a pig model of myocardial ischemia and reperfusion?

Population

27 anaesthetised open-chest pigs undergoing 45 min of left anterior descending coronary artery (LAD) occlusion

Design

Preclinical

Follow-up

4 hours of reperfusion

Authors

GKGöran KällnerInterventional / Structural Cardiology

Discussion

Member takes

Implication

CGRP retroinfusion does not reduce infarct size in pigs; leaves open any role in human myocardial reperfusion injury.

Structured PICO

Does retroinfusion of CGRP reduce infarct size in a pig model of myocardial ischemia and reperfusion?

Population

27 anaesthetised open-chest pigs undergoing 45 min of left anterior descending coronary artery (LAD) occlusion

Intervention

Retroinfusion of CGRP (100 micrograms) or CGRP antagonist CGRP(8-37) into the ischaemic myocardium

Outcome

Extent of myocardial infarction (infarct size in relation to the area at risk)surrogate

Exogenously administered CGRP augments postischemic coronary flow and causes systemic hypotension but does not reduce infarct size in a porcine model of myocardial ischemia-reperfusion.

Cite This Study

Göran Källner (1998) studied this question.

synapsesocial.com/papers/6a78de6c9fd4195bcd5acbf3 https://doi.org/10.1016/s0008-6363(98)00016-9

Topics

Women and heart disease

View Full Paper

Ask AI

Bookmark

Calcitonin gene-related peptide in myocardial ischaemia and reperfusion in the pig

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Calcitonin gene-related peptide in myocardial ischaemia and reperfusion in the pig

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider