Key result
In isolated rat hearts, CGRP administration significantly attenuated the anaerobic changes and macrohemodynamic alterations induced by endothelin-1 (p<0.05).
Why the study?
Does CGRP ameliorate myocardial ischemia induced by ET-1 in isolated rat hearts?
Population
Langendorff preparations of rat isolated heart exposed to endothelin-1 (ET-1)
Comparison
Intracoronary bolus injections of Calcitonin… vs Vehicle administration
Design
Preclinical
Authors
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May attenuate ET-1 ischemia in rat hearts; hypothesis-generating and leaves clinical translation open.
Does CGRP ameliorate myocardial ischemia induced by ET-1 in isolated rat hearts?
p-value: p=<0.05
CGRP effectively confers hemodynamic and metabolic protections to isolated beating hearts against ET-1-induced myocardial ischemia.
Homma et al. (2014) studied Myocardial ischemia induced by endothelin-1. Calcitonin gene-related peptide (CGRP) vs. Vehicle was evaluated on Coronary perfusion pressure, microvascular blood flow, and energy-related metabolites (p=<0.05). In isolated rat hearts, CGRP administration significantly attenuated the anaerobic changes and macrohemodynamic alterations induced by endothelin-1 (p<0.05).
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