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August 1, 1985Annals of Neurology

Investigation of human mitochondrial myopathies by phosphorus magnetic resonance spectroscopy

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Why the study?

Can phosphorus magnetic resonance spectroscopy detect metabolic abnormalities in patients with mitochondrial myopathy?

Population

12 patients with mitochondrial myopathy

Design

Case_series

Authors

DADouglas L. ArnoldDTD.J. TaylorGRG. K. Radda

Discussion

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Overview

31P-MRS may detect resting metabolic defects in mitochondrial myopathy; hypothesis-generating and should not yet change practice.

Structured PICO

Can phosphorus magnetic resonance spectroscopy detect metabolic abnormalities in patients with mitochondrial myopathy?

P
Population
12 patients with mitochondrial myopathy
I
Intervention
Phosphorus magnetic resonance spectroscopy of human skeletal muscle in vivo
O
Outcome
Metabolism of high-energy phosphates and intracellular pH of human skeletal muscle at rest, during exercise, and recoverysurrogate

Phosphorus magnetic resonance spectroscopy is a useful noninvasive tool for diagnosing mitochondrial myopathies and defining their pathophysiological basis.

Cite This Study

Arnold et al. (1985) studied this question.

synapsesocial.com/papers/6a78e3ea4353fbf06001fc0dhttps://doi.org/10.1002/ana.410180205
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Contraction and recovery of living muscles studied by <sup>31</sup>p nuclear magnetic resonance1977 · 295 citations
  2. 2Determination of Intracellular pH by 31P Magnetic Resonance1973 · 1,192 citations
  3. 3Application of 31P-NMR spectroscopy to the study of striated muscle metabolism1982 · 307 citations
  4. 4Nuclear magnetic resonance studies of forearm muscle in Duchenne dystrophy.1982 · 168 citations
  5. 531P NMR study of improvement in oxidative phosphorylation by vitamins K3 and C in a patient with a defect in electron transport at complex III in skeletal muscle.1984 · 275 citations